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Eli Lilly has signed a deal worth $1.3 billion with privately held Superluminal Medicines to discover and develop small-molecule drugs through AI to treat obesity and other cardiometabolic diseases. Lilly currently dominates the obesity treatment market, which is estimated to be worth $150 billion by the next decade, and is trying to strengthen its foothold in the space through the development of next-generation drugs, acquisitions and partnerships. The deal gives Lilly access to Superluminal’s proprietary artificial-intelligence-driven platform to rapidly discover potential drug candidates targeting G-protein-coupled receptors (GPCR)a class of proteins that can influence a range of physiological processes including metabolism, cell growth and immune responsesthe drug developer said on Thursday. In a similar move, Danish rival Novo Nordisk struck a $2.2 billion deal with U.S. biotech Septerna in May to develop oral small-molecule medicines targeting GPCRs for obesity and other cardiometabolic diseases. Lilly has been capitalizing on the overwhelming popularity of the GLP-1 class of medicines, which includes its blockbuster drug Zepbound as well as Novo’s Wegovy. It is also developing a keenly watched oral GLP-1 drug, orforglipron, which has failed to meet investors’ lofty expectations. The drugmaker teamed up with Hong Kong-listed biotech Laekna last year to develop an experimental obesity drug that aims to help patients lose weight while preserving muscle. Lilly will receive exclusive rights to develop and commercialize drug candidates discovered using Superluminal’s platform, the drug developer said. As part of the deal, Superluminal is eligible to receive upfront and milestone payments, an equity investment as well as tiered royalties on net sales, the company said. Boston-based startup Superluminal is developing a wholly owned lead candidate targeting a protein called melanocortin 4 receptor to treat certain rare, genetic forms of obesity and is expected to begin human trials next year. The lead candidate is not part of the deal with Lilly. Superluminal is backed by investors including RA Capital Management, Insight Partners and NVentures, NVIDIA’s venture capital arm. Mariam Sunny, Reuters
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Werner on Thursday said it is recalling more than 100,000 faulty ladders due to a locking mechanism that can fail, potentially causing users to fall and injure themselves. In cooperation with federal consumer product regulators, Werner is recalling 122,250 Multi-Max Pro ladders that come in 20-foot and 24-foot sizes. The ladders were sold exclusively at Home Depot between November of 2021 and February of 2024 with prices between $200 and $281. The Illinois-based company said owners of the ladders being recalled should stop using them immediately and register at www.wernerco.com/recalls to begin the process for a full refund. Once owners have properly disposed of their ladders per Werner’s instructions, the company said it will issue a check for a full refund. The ladders are silver with a blue top and a blue label on the side rail with an oval containing the word Werner and MULTI MAX PRO. The size and model numbers are ALMP-20IAA or ALMP-24IAA and have a long black rope in the back. Werner said it has received 18 reports of falls, including 14 reports of injuries resulting in bruising, lacerations, head injuries and fractures to the wrist, leg and ribs. If consumers think they own a ladder being recalled, they can call Werner at 888-624-1907 from 8:30 a.m. to 6 p.m. Eastern time Monday through Friday or email ladder@realtimeresults.net. More information can be found online at http://www.wernerco.com/recalls or by clicking on Recalls at the bottom of Werner’s home page. The recall number is 25-431. Werner noted that models ALMP-16IAA and ALMP-18IAA Multi-Max Pro Ladders currently offered for sale have a different design and are not included in the recall.
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E-Commerce
Corporate America has historically believed in the power of the company offsite. Executives are whisked away to remote locations where they sip mediocre coffee in meeting rooms and strategize before catered lunches arrive. Meanwhile, parents, quite possibly the most overworked and understaffed management team on earth, rarely get more than a solo run to the grocery store. If theyre really lucky, they might get to enjoy five minutes in the shower before someone is pounding on the bathroom door. I say its time to correct the imbalance. Parents need offsites too. Not just the once-in-a-decade vacation you take after a major anniversary or a milestone birthday. I am talking about regular, kid-free weekends scheduled with the same urgency as a company budget review. The reason? For many of us, the home teams long-term growth plan is being held together with caffeine and prayer. The power of short breaks This idea isnt frivolous. Research consistently shows that parents experience higher daily stress levels than their child-free peers, reporting more fatigue, less leisure time, and higher rates of burnout. A 2022 study aptly titled Give me a break! found that short breaks from duties can boost mood and reduce fatigue. Think of it as mental maintenance. You wouldnt run your car for 100,000 miles without an oil change so why run yourself ragged without pausing to recharge? {"blockType":"creator-network-promo","data":{"mediaUrl":"https:\/\/images.fastcompany.com\/image\/upload\/f_webp,q_auto,c_fit\/wp-cms-2\/2015\/08\/erikaaslogo.png","headline":"Girl, Listen: A Guide to What Really Matters","description":"Ericka dives into the heat of modern motherhood, challenging the notion that personal identity must be sacrificed at the altar of parenting. ","substackDomain":"https:\/\/erickasouter.substack.com\/","colorTheme":"blue","redirectUrl":""}} And collapsing on the couch after the bedtime routine doesnt count. An offsite is different. Its a deliberate escape from your usual day-to-day, designed to give you space to reflect, restore, and maybe even remember who you were before you became a chauffeur, short order cook, and 24/7 project manager for both home and work. The logistics So how do you make this happen? Arranging childcare for a weekend is tough. But this is a time to call in favors or rely on grandparents, godparents, and other extended family. Some parents even negotiate a swap with other families they are close to: You take my kids for a weekend next month and I will return the favor. And for those already formulating counterarguments, lets address: Its expensive. What you do with this free time doesnt matter and there is no need to go far away. Book an Airbnb in a nearby town and wander through bookstores, take naps, eat dinner in front of a hotel TV. Its hard to find time. You find time for everyone else. Put yourself on top of the to-do list for a day or so. Besides, protecting your own mental health is an insurance policy. Ill feel guilty. Guilt is the ever-present background music of parenthood. You might as well let it play while sipping your coffee in peace someplace. Your family will survive without you for a couple days. Rested and recharged You are stepping away to ensure your team keeps functioning smoothly. Every parent needs a moment when no one is demanding crayons, asking you to cut their chicken, or provide a market update for the morning meeting. You will come back recharged, patient, and more capable of tolerating the next crisis.There is also the added benefit of positive parental modeling. When your kids see you prioritize your own well-being, they learn that self-care isnt optional. Everyone around you will see that rest is part of a sustainable life, not a luxury. And dont you want them to grow into adults who know how to step back before they break down? Besides, the world doesnt need another burned out parent. It needs you at your sharpest, and sometimes that means packing a bag. {"blockType":"creator-network-promo","data":{"mediaUrl":"https:\/\/images.fastcompany.com\/image\/upload\/f_webp,q_auto,c_fit\/wp-cms-2\/2015\/08\/erikaaslogo.png","headline":"Girl, Listen: A Guide to What Really Matters","description":"Ericka dives into the heat of modern motherhood, challenging the notion that personal identity must be sacrificed at the altar of parenting. ","substackDomain":"https:\/\/erickasouter.substack.com\/","colorTheme":"blue","redirectUrl":""}}
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